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Medication Comparison

Compare any two to four medications side by side — what is actually in them, how strong they are, how they are taken and who makes them. Built on the 112,035 products in the US FDA National Drug Code directory.

  • 56,435Prescription
  • 55,600Over the counter
  • 3,850Active ingredients
  • 36,475We stock the ingredient

876 medications

Tick up to 4 to compare.

NAPROXEN SODIUM PM

diphenhydramine hydrochloride, naproxen sodium

Strength
25 mg/1, 220 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

Safeway

Not stocked by us — reference only

naproxen sodium pm

diphenhydramine hydrochloride, naproxen sodium

Strength
25 mg/1, 220 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

Kroger Company

Not stocked by us — reference only

naproxen sodium pm

diphenhydramine hydrochloride, naproxen sodium

Strength
25 mg/1, 220 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

H E B

Not stocked by us — reference only

naproxen sodium pm

diphenhydramine hydrochloride, naproxen sodium

Strength
25 mg/1, 220 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

Meijer Distribution Inc

Not stocked by us — reference only

Nighttime Cold and Cough childrens

Diphenhydramine HCl, Phenylephrine HCl

Strength
6.25 mg/5mL, 2.5 mg/5mL
Form
Liquid
Class
Histamine-1 Receptor Antagonist; alpha-…
OTC

Best Choice (Valu Merchandisers Company)

Not stocked by us — reference only

Nighttime Sleep Aid

acetaminophen, diphenhydramine

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Hi-Tech Nutraceuticals, LLC

Not stocked by us — reference only

Pain Relief PM

ACETAMINOPHEN, DIPHENHYDRAMINE

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Pioneer Life Sciences, LLC

Not stocked by us — reference only

Pain Relief PM

ACETAMINOPHEN, DIPHENHYDRAMINE

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Pioneer Life Sciences, LLC

Not stocked by us — reference only

Pain Relief PM

ACETAMINOPHEN, DIPHENHYDRAMINE

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

NUVICARE LLC

Not stocked by us — reference only

Rite Aid Itch Relief

Diphenhydramine HCl 2%, Zinc Acetate 0.1%

Strength
2 g/100g, .1 g/100g
Form
Spray
Class
Copper Absorption Inhibitor; Histamine-…
OTC

Rite Aid

Not stocked by us — reference only

SanaTos Severe Cold Relief Nighttime

Acetaminophen, Diphenhydramine hydrochloride, and Phenylephrine hydro…

Strength
650 mg/1, 25 mg/1, 10 mg/1
Form
Granule, For Solution
Class
Histamine-1 Receptor Antagonist; alpha-…
OTC

Pharmadel LLC

Not stocked by us — reference only

Savvy Itch Stopping

Diphenhydramine hydrochloride Zinc acetate

Strength
2 g/100g, .1 g/100g
Form
Cream
Class
Copper Absorption Inhibitor; Histamine-…
OTC

Savvy Care and Cosmetics

Not stocked by us — reference only

Shopko Anti-Itch

diphenhydramine hydrochloride and zinc acetate

Strength
20 mg/g, 1 mg/g
Form
Cream
Class
Copper Absorption Inhibitor; Histamine-…
OTC

Shopko Stores Operating Co., LLC

Not stocked by us — reference only

signature care itch relief

Diphenhydramine Hydrochloride, Zinc Acetate

Strength
2 g/100g, .1 g/100g
Form
Cream
Class
Copper Absorption Inhibitor; Histamine-…
OTC

Safeway

Not stocked by us — reference only

TACT

diphenhydramine hydrochloride, menthol

Strength
2 g/100g, 1 g/100g
Form
Cream
Class
Histamine-1 Receptor Antagonist
OTC

Sato Pharmaceutical Inc., Ltd.

Not stocked by us — reference only

Tact Cool Jelly

diphenhydramine hydrochloride, levomenthol

Strength
2 g/100g, 1 g/100g
Form
Gel
Class
Histamine-1 Receptor Antagonist
OTC

Sato Pharmaceutical Co., Ltd.

Not stocked by us — reference only

TheraCare 2% Diphenhydramine Anti-Itch Cream

Diphenhydramine Hydrochloride and Zinc Acetate

Strength
20 mg/g, 1 mg/g
Form
Cream
Class
Copper Absorption Inhibitor; Histamine-…
OTC

Veridian Healthcare

Not stocked by us — reference only

topcare all night pain relief pm

diphenhydramine hydrochloride, naproxen sodium

Strength
25 mg/1, 220 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

Topco Associates LLC

Not stocked by us — reference only

topcare anti itch

diphenhydramine hydrochloride, zinc acetate

Strength
2 g/100g, .1 g/100g
Form
Cream
Class
Copper Absorption Inhibitor; Histamine-…
OTC

Topco Associates LLC

Not stocked by us — reference only

Topcare Ibuprofen PM

diphenhydramine citrate and ibuprofen

Strength
38 mg/1, 200 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

Topco Associates LLC

Not stocked by us — reference only

Tylenol PM Extra Strength, CVP HEALTH

Acetaminophen and Diphenhydramine Hydrochloride

Strength
500 mg/1, 25 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist
OTC

Lil' Drug Store Products, Inc.

Not stocked by us — reference only

up and up ibuprofen pm

diphenhydramine citrate and ibuprofen

Strength
38 mg/1, 200 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist; Nonste…
OTC Generic

Target Corporation

Not stocked by us — reference only

How to read a comparison

Same ingredient, different name

Most medications exist under several names: one brand name, one generic name, and a different brand again in another country. What matters is the active ingredient and its strength — two products with the same ingredient at the same strength are, for most purposes, the same medicine.

Strength is not a measure of quality

A 10 mg tablet is not "better" than a 5 mg one. Strength is matched to the person and the condition, and a higher one is not an upgrade. Only your prescriber can say which is right for you.

Dosage form changes more than convenience

The same ingredient as a tablet, a capsule or a liquid can be absorbed at different speeds. Modified-release forms in particular are not interchangeable with ordinary ones, even at an identical stated strength.

Approval route

NDA is an original brand-name approval. ANDA is a generic, which had to prove it delivers the ingredient to the bloodstream at a rate and extent statistically equivalent to the original. OTC monograph covers products sold without a prescription under standing FDA rules.

Controlled substances

A DEA schedule badge means the medication is federally controlled because of its potential for dependence or misuse. Schedule II is the most tightly restricted of those available by prescription. These carry extra rules on prescribing, refills and supply.

What "we supply this ingredient" means

Where we stock a product containing the same active ingredient, the card says so and links to it. That is an ingredient match — the strength, form or manufacturer of what we sell may differ from the FDA record shown, so check the product page before ordering.

This tool is for information only and is not medical advice. It cannot tell you whether a medication is safe or suitable for you, and nothing here replaces a conversation with a prescriber or pharmacist. Source data is published by the U.S. Food & Drug Administration via openFDA and is reproduced without their endorsement; the FDA states it should not be relied upon for decisions about medical care.