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Medication Comparison

Compare any two to four medications side by side — what is actually in them, how strong they are, how they are taken and who makes them. Built on the 112,035 products in the US FDA National Drug Code directory.

  • 56,435Prescription
  • 55,600Over the counter
  • 3,850Active ingredients
  • 36,475We stock the ingredient

2,765 medications

Tick up to 4 to compare.

Pain Relief Sinus Congestion

Acetaminophen, Phenylephrine HCl

Strength
325 mg/1, 5 mg/1
Form
Tablet, Film Coated
Class
alpha-1 Adrenergic Agonist
OTC

Better Living Brands, LLC

Not stocked by us — reference only

Pain Reliever

Acetaminophen, Ibuprofen

Strength
250 mg/1, 125 mg/1
Form
Tablet, Film Coated
Class
Nonsteroidal Anti-inflammatory Drug
OTC Generic

CVS Pharmacy

Not stocked by us — reference only

Pain Reliever Extra Strength

Acetaminophen, Aspirin and caffeine

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet, Film Coated
Class
Central Nervous System Stimulant; Methy…
OTC

Rite Aid Corporation

Not stocked by us — reference only

Pain Reliever plus Sleep Aid NightTime

Acetaminophen, Diphenhydramine HCl

Strength
1000 mg/30mL, 50 mg/30mL
Form
Solution
Class
Histamine-1 Receptor Antagonist
OTC

Kroger Company

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist
OTC

Walgreen Company

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

TARGET Corporation

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist
OTC

L.N.K. International, Inc.

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCL

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

CVS PHARMACY, INC

Not stocked by us — reference only

Pain Reliever PM

ACETAMINOPHEN, DIPHENHYDRAMINE HYDROCHLORIDE

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Magno-Humphries, Inc.

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

Family Dollar (FAMILY WELLNESS)

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

WR Group, Inc.

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

Strategic Sourcing Services LLC

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

WALMART INC.

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine Hydrochloride

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Walmart Inc.

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist
OTC

WALMART INC.

Not stocked by us — reference only

Pain Reliever PM

Acetaminophen Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

QUALITY CHOICE (Chain Drug Marketing Associatio…

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

Walgreen Company

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

Walgreens

Not stocked by us — reference only

Pain Reliever PM Extra strength

Acetaminophen, Diphenhydramine HCL

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

Walgreens

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

TOP CARE (Topco Associates LLC)

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MA…

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCL

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

Big Lots

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Film Coated
Class
Histamine-1 Receptor Antagonist
OTC

L.N.K. International, Inc.

Not stocked by us — reference only

Pain Reliever PM Extra Strength

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

L.N.K. International, Inc.

Not stocked by us — reference only

How to read a comparison

Same ingredient, different name

Most medications exist under several names: one brand name, one generic name, and a different brand again in another country. What matters is the active ingredient and its strength — two products with the same ingredient at the same strength are, for most purposes, the same medicine.

Strength is not a measure of quality

A 10 mg tablet is not "better" than a 5 mg one. Strength is matched to the person and the condition, and a higher one is not an upgrade. Only your prescriber can say which is right for you.

Dosage form changes more than convenience

The same ingredient as a tablet, a capsule or a liquid can be absorbed at different speeds. Modified-release forms in particular are not interchangeable with ordinary ones, even at an identical stated strength.

Approval route

NDA is an original brand-name approval. ANDA is a generic, which had to prove it delivers the ingredient to the bloodstream at a rate and extent statistically equivalent to the original. OTC monograph covers products sold without a prescription under standing FDA rules.

Controlled substances

A DEA schedule badge means the medication is federally controlled because of its potential for dependence or misuse. Schedule II is the most tightly restricted of those available by prescription. These carry extra rules on prescribing, refills and supply.

What "we supply this ingredient" means

Where we stock a product containing the same active ingredient, the card says so and links to it. That is an ingredient match — the strength, form or manufacturer of what we sell may differ from the FDA record shown, so check the product page before ordering.

This tool is for information only and is not medical advice. It cannot tell you whether a medication is safe or suitable for you, and nothing here replaces a conversation with a prescriber or pharmacist. Source data is published by the U.S. Food & Drug Administration via openFDA and is reproduced without their endorsement; the FDA states it should not be relied upon for decisions about medical care.