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Medication Comparison

Compare any two to four medications side by side — what is actually in them, how strong they are, how they are taken and who makes them. Built on the 112,035 products in the US FDA National Drug Code directory.

  • 56,435Prescription
  • 55,600Over the counter
  • 3,850Active ingredients
  • 36,475We stock the ingredient

2,765 medications

Tick up to 4 to compare.

EXTRA PAIN RELIEF

ACETAMINOPHEN, ASPIRIN AND CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet, Film Coated
Class
Central Nervous System Stimulant; Methy…
OTC

TIME CAP LABS

Not stocked by us — reference only

EXTRA STRENGHT HEADACHE RELIEF

acetaminophen, aspirin, caffeine

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

Lil' Drug Store Products, Inc.

Not stocked by us — reference only

Extra Strength Acetaminophen PM

Acetaminophen and Diphenhydramine Hydrochloride

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

KROGER COMPANY

Not stocked by us — reference only

Extra Strength Acetaminophen PM

Acetaminophen, Diphenhydramine

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

BJWC (Berkley & Jensen / BJ's)

Not stocked by us — reference only

EXTRA STRENGTH HEADACHE RELIEF

ACETAMINOPHEN, ASPIRIN, CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

WALGREENS

Not stocked by us — reference only

EXTRA STRENGTH HEADACHE RELIEF

ACETAMINOPHEN, ASPIRIN, CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

WALGREENS

Not stocked by us — reference only

Extra Strength Headache Relief

acetaminophen, aspirin, and caffeine

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

Lil' Drug Store Products, Inc.

Not stocked by us — reference only

Extra Strength Headache Relief

acetaminophen, aspirin, and caffeine

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet, Coated
Class
Central Nervous System Stimulant; Methy…
OTC

Dollar General

Not stocked by us — reference only

Extra Strength Headache Relief

Acetaminophen, Aspirin, and Caffeine

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

Advanced Rx LLC

Not stocked by us — reference only

EXTRA STRENGTH Headache Relief geltabs

Acetaminophen, Aspirin, Caffeine

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

Strive Pharmaceuticals Inc.

Not stocked by us — reference only

Extra Strength Headache, Lil Drug Store

EXTRA STRENGHT HEADACHE RELIEF- acetaminophen, aspirin, caffeine tabl…

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

Lil' Drug Store Products, Inc.

Not stocked by us — reference only

Extra Strength Night Time Pain Medicine

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Geri-Care Pharmaceutical Corp

Not stocked by us — reference only

Extra Strength Nite-Time Pain Relief

430R WALGREENS Acetaminophen 500 mg,Diphenhydramine HCl 25 mg Tablet

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

WALGREENS

Not stocked by us — reference only

Extra Strength Pain Relief PM

Acetaminophen and Diphenhydramine Hydrochloride

Strength
500 mg/1, 25 mg/1
Form
Tablet, Coated
Class
Histamine-1 Receptor Antagonist
OTC

VALU MERCHANDISERS COMPANY

Not stocked by us — reference only

EXTRA STRENGTH PAIN RELIEVER

ACETAMINOPHEN, ASPIRIN AND CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet, Film Coated
Class
Central Nervous System Stimulant; Methy…
OTC

Geri-Care Pharmaceutical Corp

Not stocked by us — reference only

Extra Strength Pain Reliever

ACETAMINOPHEN, ASPIRIN, and CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Capsule, Coated
Class
Central Nervous System Stimulant; Methy…
OTC

JHK Inc dba American Safety & First Aid

Not stocked by us — reference only

EXTRA STRENGTH PAIN RELIEVER

ACETAMINOPHEN, ASPIRIN AND CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet, Film Coated
Class
Central Nervous System Stimulant; Methy…
OTC

Proficient Rx LP

Not stocked by us — reference only

EXTRA STRENGTH PAIN RELIEVER PM

ACETAMINOPHEN AND DIPHENHYDRAMINE HYDROCHLORIDE

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

WALGREENS CO.

Not stocked by us — reference only

Extra Strength Pain Reliever PM

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

INGLES MARKETS, INC.

Not stocked by us — reference only

EXTRA STRENGTH PAIN RELIEVER PM

ACETAMINOPHEN AND DIPHENHYDRAMINE HYDROCHLORIDE

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

WALMART INC.

Not stocked by us — reference only

Extra Strength PM Pain Medicine

Acetaminophen, Diphenhydramine HCl

Strength
500 mg/1, 25 mg/1
Form
Tablet
Class
Histamine-1 Receptor Antagonist
OTC

Amerisource Bergen

Not stocked by us — reference only

Extra Strength TYLENOL Severe Cough Plus Sore Throat Night

Acetaminophen, Dextromethorphan Hydrobromide and Doxylamine Succinate.

Strength
1000 mg/30mL, 30 mg/30mL, 12.5 mg/30mL
Form
Liquid
Class
Antihistamine; Sigma-1 Agonist; Uncompe…
OTC

Kenvue Brands LLC

Not stocked by us — reference only

Extraprin

ACETAMINOPHEN, ASPIRIN, CAFFEINE

Strength
250 mg/1, 250 mg/1, 65 mg/1
Form
Tablet
Class
Central Nervous System Stimulant; Methy…
OTC

Magno-Humphries, Inc.

Not stocked by us — reference only

How to read a comparison

Same ingredient, different name

Most medications exist under several names: one brand name, one generic name, and a different brand again in another country. What matters is the active ingredient and its strength — two products with the same ingredient at the same strength are, for most purposes, the same medicine.

Strength is not a measure of quality

A 10 mg tablet is not "better" than a 5 mg one. Strength is matched to the person and the condition, and a higher one is not an upgrade. Only your prescriber can say which is right for you.

Dosage form changes more than convenience

The same ingredient as a tablet, a capsule or a liquid can be absorbed at different speeds. Modified-release forms in particular are not interchangeable with ordinary ones, even at an identical stated strength.

Approval route

NDA is an original brand-name approval. ANDA is a generic, which had to prove it delivers the ingredient to the bloodstream at a rate and extent statistically equivalent to the original. OTC monograph covers products sold without a prescription under standing FDA rules.

Controlled substances

A DEA schedule badge means the medication is federally controlled because of its potential for dependence or misuse. Schedule II is the most tightly restricted of those available by prescription. These carry extra rules on prescribing, refills and supply.

What "we supply this ingredient" means

Where we stock a product containing the same active ingredient, the card says so and links to it. That is an ingredient match — the strength, form or manufacturer of what we sell may differ from the FDA record shown, so check the product page before ordering.

This tool is for information only and is not medical advice. It cannot tell you whether a medication is safe or suitable for you, and nothing here replaces a conversation with a prescriber or pharmacist. Source data is published by the U.S. Food & Drug Administration via openFDA and is reproduced without their endorsement; the FDA states it should not be relied upon for decisions about medical care.